Let's try to narrow it down to a video vs. audio problem.
- First, try using D3D mode: http://www.hemispheregames.com/faq-pcos ... /#tech_d3d
- If that doesn't work, try running without sound for a while: http://www.hemispheregames.com/faq-pcos ... soundcrash
Hopefully one of those tests results in a crash-free setup for you. If it's sound, we'll try to find a way to get you running with it re-enabled again. No sound = no fun.

Cheers,
Eddy